Liquid Biopsy for Cancer
Current Status and Future Challenges
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Beschreibung
Individual tumour molecular profiling and tracking dynamic evolution by treatment related selective pressure are crucial for clinical oncology. However, current tissue biopsy cannot represent spatial and temporal tumour heterogeneity due to sampling bias.
Liquid biopsy is an alternative way of tissue biopsy since it can represent comprehensive molecular signature from multiple distinct lesions and real time tracking is feasible by repeated longitudinal assay during course of treatment.
This book describes current knowledge regarding pre-analytical issues including standardization of blood preparation, analytical variability, clinical application and regulatory agency approval issue, etc. Regarding targets in circulation, it focuses on circulating tumour cells (CTCs), circulating nucleic acid (ctDNA, cell free RNAs), extracellular vesicles, tumour educated platelets, and others (proteins, metabolites).
The book will be a rich source of information and instruction for oncologists and offers stimulating ideas on prospects for further progress in this field.
The translation was done with the help of artificial intelligence. A subsequent human revision was done primarily in terms of content.
Individual tumour molecular profiling and tracking dynamic evolution by treatment related selective pressure are crucial for clinical oncology. However, current tissue biopsy cannot represent spatial and temporal tumour heterogeneity due to sampling bias.
Liquid biopsy is an alternative way of tissue biopsy since it can represent comprehensive molecular signature from multiple distinct lesions and real time tracking is feasible by repeated longitudinal assay during course of treatment.
This book describes current knowledge regarding pre-analytical issues including standardization of blood preparation, analytical variability, clinical application and regulatory agency approval issue, etc. Regarding targets in circulation, it focuses on circulating tumour cells (CTCs), circulating nucleic acid (ctDNA, cell free RNAs), extracellular vesicles, tumour educated platelets, and others (proteins, metabolites).
The book will be a rich source of information and instruction for oncologists and offers stimulating ideas on prospects for further progress in this field.
The translation was done with the help of artificial intelligence. A subsequent human revision was done primarily in terms of content.
Describes current knowledge regarding pre-analytical issues of liquid biopsy Represent comprehensive molecular signature from multiple distinct lesions and real time tracking of tissue biopsy Addresses a wide range of technical issues and viewpoints
Autor*in
Seung Il Kim
Themen in »Liquid Biopsy for Cancer«
liquid biopsy cancer screening treatment monitoring ctDNA circulating tumour cells