The Biological Role of Small Leucine-Rich Proteoglycans (SLRPs) in Matrix Homeostasis and Diseases
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Beschreibung
This book covers advanced and up-to-date analyses of the synthesis, fragmentation, and dysregulation of Small Leucine-Rich Proteoglycans (SLRPs) in some common matrix-related diseases. These SLRPs act as autonomous triggers of inflammation in conditions such as cancer, cartilage tissue degeneration, renal (kidney) diseases, as well as skin, tendon, musculoskeletal, and craniofacial tissues, responding to stress, injury, and impairment of normal function.
Chapters describe the significance behind the formation of proteolytic molecular fragments of SLRPs and why they alter inflammatory cell-signaling pathways, acting as Damage-Associated Molecular Patterns (DAMPs), that can function as Pathogen-Associated Molecular Patterns (PAMPs) in the early, intermediate, and advanced stages of matrix dysregulation and diseases. It also discusses evidence-based therapeutic approaches useful for identifying molecular fragments as potential biomarkers of matrix degeneration, providing a thorough understanding on the regulatory role of SLRPs in matrix homeostasis and diseases. The book is supplemented with well-illustrated figures, tabulated analysis, and critical review questions for further investigations that identifies gap in current understanding.
The book is relevant for experts in medical sciences specializing in cell, extracellular matrix-based tissue analysis, researchers, as well as students interested in investigating matrix-related changes during the pathological progression of diseases.
This book covers advanced and up-to-date analyses of the synthesis, fragmentation, and dysregulation of Small Leucine-Rich Proteoglycans (SLRPs) in some common matrix-related diseases. These SLRPs act as autonomous triggers of inflammation in conditions such as cancer, cartilage tissue degeneration, renal (kidney) diseases, as well as skin, tendon, musculoskeletal, and craniofacial tissues, responding to stress, injury, and impairment of normal function.
Chapters describe the significance behind the formation of proteolytic molecular fragments of SLRPs and why they alter inflammatory cell-signaling pathways, acting as Damage-Associated Molecular Patterns (DAMPs), that can function as Pathogen-Associated Molecular Patterns (PAMPs) in the early, intermediate, and advanced stages of matrix dysregulation and diseases. It also discusses evidence-based therapeutic approaches useful for identifying molecular fragments as potential biomarkers of matrix degeneration, providing a thorough understanding on the regulatory role of SLRPs in matrix homeostasis and diseases. The book is supplemented with well-illustrated figures, tabulated analysis, and critical review questions for further investigations that identifies gap in current understanding.
The book is relevant for experts in medical sciences specializing in cell, extracellular matrix-based tissue analysis, researchers, as well as students interested in investigating matrix-related changes during the pathological progression of diseases.
Includes class-wise description and comparisons of SLRPs in diseases of the matrix Provides easy-to-follow definitions with tabular analyses of SLRP fragments and critical review-based questions Discusses therapeutic approaches behind SLRPs fragments as potential biomarkers in diseases
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Polly Lama
Themen in »The Biological Role of Small Leucine-Rich Proteoglycans (SLRPs) in Matrix Homeostasis and Diseases«
Cell-matrix biology Leucine-rich repeats (LRRs) Cell-extracellular matrix-signaling Cell-cell receptors Molecular fragments of small leucine-rich proteoglycans (SLRPs) Craniofacial tissue degradation SLRPs fragments as biomarkers Renal tissue fibrosis SLRPs in matrix dysregulations Molecular fragments of SLRPs as DAMPs