Gene Expression and its Regulation: An Evolutionary Perspective
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Beschreibung
This textbook for graduate students provides a conceptual framework for comprehending the diversity and evolutionary relationships of gene regulatory systems. It elucidates the importance and significance of the physical and chemical principles that underpin gene regulatory processes. The Chapters of the book may be conceptually divided into six sections; the first section, consisting of Chapters 1 and 2, presents the basic organization of genes, genomes, and aspects of gene regulation in three domains of life. The second section, consisting of Chapters 3-5 describes the process of gene expression as it goes from the DNA sequence embedded in the genome to the final functional protein. The third section, consisting of Chapter 6, discusses special characteristics of gene expression within cells. The fourth section, consisting of Chapters 7-10 discusses how genes are regulated in different domains of life. The fifth section, consisting of Chapter 11, presents details of gene regulatory systems in three domains of life; archaea, eubacteria, and eukarya and their evolutionary relationship. In the final section, consisting of Chapter 12, the book underscores the potential to artificially intervene and alter gene regulation and attempts to re-engineer gene regulatory circuits.
This textbook for graduate students provides a conceptual framework for comprehending diversity and evolutionary relationships of gene regulatory systems. It elucidates the importance and significance of the physical and chemical principles that underpin gene regulatory processes. The introductory section presents the core principles of the organization of genes, genomes, and aspects of gene regulation in three domains of life. The subsequent narrative then describes the process of gene expression as it goes from the DNA sequence embedded in the genome to the final functional protein. The book then describes how genes are regulated in different domains of life, the principal focus of the book, with considerable mechanistic details. This section also discusses the evolutionary relationships of gene regulatory systems in three domains of life: archaea, eubacteria, and eukarya. In the final section, the book underscores the potential to artificially intervene and alter gene regulation and describes attempts to re-engineer gene regulatory circuits.
Discusses physical and chemical principles underlying gene regulatory systems Presents diverse gene regulatory system in diverse organisms and their evolutionary relationships Covers distinctive features of eubacterial and eukaryotic transcription
Autor*in
Siddhartha Roy
Themen in »Gene Expression and its Regulation: An Evolutionary Perspective«
Gene expression Regulation Evolution Synthetic Biology Epigenetics