Ubiquitin Proteasome System in CNS Neurodegenerative Diseases
Buch in deiner Nähe kaufen
Beschreibung
This book provides up-to-date information on the mechanisms of protein degradation and highlights the significance of protein quality control for cellular physiology and pathology specifically in CNS neurodegenerative diseases. Chapters cover cellular bioenergetics, environmental factors, protein load, and their respective roles in the pathogenesis and progression of diseases. Additionally, the book addresses the array of experimental tools (models) available for studying disease etiology, progression, and therapeutics, offering a balanced discussion of their advantages and disadvantages. It provides insights into the effects of both sporadic and genetic models in investigating disease mechanisms, with a perspective on experimental model systems.
The book is relevant for scientists and researchers in the fields of neuroscience, cellular signaling, protein, and systems biology. It is also valuable for clinicians interested in both basic and translational research in the field of central nervous system (CNS) neurodegenerative diseases.
This book provides up-to-date information on the mechanisms of protein degradation and highlights the significance of protein quality control for cellular physiology and pathology specifically in CNS neurodegenerative diseases. Chapters cover cellular bioenergetics, environmental factors, protein load, and their respective roles in the pathogenesis and progression of diseases. Additionally, the book addresses the array of experimental tools (models) available for studying disease etiology, progression, and therapeutics, offering a balanced discussion of their advantages and disadvantages. It provides insights into the effects of both sporadic and genetic models in investigating disease mechanisms, with a perspective on experimental model systems.
The book is relevant for scientists and researchers in the fields of neuroscience, cellular signaling, protein, and systems biology. It is also valuable for clinicians interested in both basic and translational research in the field of central nervous system (CNS) neurodegenerative diseases.
Discusses therapeutics for dysfunctional ubiquitin-proteasome system (UPS) Includes benefits and drawbacks of sporadic and genetic models Analyzes bioenergetics' role in degenerative events and neuroprotective mechanisms
Autor*in
Sarika Singh
Themen in »Ubiquitin Proteasome System in CNS Neurodegenerative Diseases«
Mechanisms of protein degradation Ubiquitin–proteasome Syatem (UPS) in Parkinson's diseases (PD) Ubiquitin–proteasome Syatem (UPS) in Alzheimer's diseases (AD) Alzheimer's signaling pathway Parkinson's signaling pathway Proteolysis in neurodegenerative diseases E3 ubiquitin ligases in Parkinson’s pathology E3 ubiquitin ligases in Alzheimer’s pathology Ubiquitin signalling in neurodegenerative diseases Protein homeostasis in neurodegenerative diseases Animal models for Parkinson's disease (PD) Animal Models of Alzheimer's disease (AD)