Core-Shell Nanoparticles for Targeted Drug Delivery Volume 2
Advances in Organ-Specific Drug Delivery and Translational Nanomedicine
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Beschreibung
This book provides a comprehensive overview of core-shell nanoparticles for stimuli-responsive, organ-specific drug delivery, combining fundamental principles with recent advances. It highlights how these nanostructures are engineered to transport therapeutic agents directly to targeted organs such as the brain, liver, lungs, kidney, breast, and pancreas through controlled architecture, functionalization, and responsiveness to local microenvironmental cues, underscoring their transformative role in precision medicine.
The background emphasizes the need for site-specific drug delivery systems that overcome limitations of conventional therapies, including poor bioavailability and systemic toxicity. Core-shell nanoparticles, with their layered design, improve drug encapsulation, stability, and biocompatibility while enabling controlled release. Their development reflects decades of progress in nanotechnology, pharmaceutics, and biomedical engineering, converging toward personalized and precision medicine.
Chapters span principles of targeted delivery, ligand-mediated strategies, and applications in personalized medicine, followed by organ-specific therapies for cancer, neurological disorders, and metabolic or endocrine diseases. Additional sections address preclinical models, clinical trials, nanotoxicology, regulatory perspectives, and commercialization challenges, enriched by contributions from international experts.
The audience includes researchers, pharmaceutical scientists, clinicians, and graduate students in nanomedicine, drug delivery, and biomaterials. Secondary readers such as healthcare professionals, industry innovators, and policymakers will also benefit. By combining foundational knowledge with translational case studies, this volume serves as both a scholarly reference and a practical guide for advancing smart therapeutics.
This book provides a comprehensive overview of core-shell nanoparticles for stimuli-responsive, organ-specific drug delivery, combining fundamental principles with recent advances. It highlights how these nanostructures are engineered to transport therapeutic agents directly to targeted organs such as the brain, liver, lungs, kidney, breast, and pancreas through controlled architecture, functionalization, and responsiveness to local microenvironmental cues, underscoring their transformative role in precision medicine.
The background emphasizes the need for site-specific drug delivery systems that overcome limitations of conventional therapies, including poor bioavailability and systemic toxicity. Core-shell nanoparticles, with their layered design, improve drug encapsulation, stability, and biocompatibility while enabling controlled release. Their development reflects decades of progress in nanotechnology, pharmaceutics, and biomedical engineering, converging toward personalized and precision medicine.
Chapters span principles of targeted delivery, ligand-mediated strategies, and applications in personalized medicine, followed by organ-specific therapies for cancer, neurological disorders, and metabolic or endocrine diseases. Additional sections address preclinical models, clinical trials, nanotoxicology, regulatory perspectives, and commercialization challenges, enriched by contributions from international experts.
The audience includes researchers, pharmaceutical scientists, clinicians, and graduate students in nanomedicine, drug delivery, and biomaterials. Secondary readers such as healthcare professionals, industry innovators, and policymakers will also benefit. By combining foundational knowledge with translational case studies, this volume serves as both a scholarly reference and a practical guide for advancing smart therapeutics.
Explores design and synthesis of core-shell nanoparticles for precise, organ-specific drug delivery Discusses applications in cancer, neurological, metabolic, infectious, and inflammatory disease therapies Highlights biocompatibility, toxicity, pharmacokinetics, and regulatory perspectives for clinical translation
Autor*in
Raj Kumar
Themen in »Core-Shell Nanoparticles for Targeted Drug Delivery Volume 2«
Core-shell nanoparticles Stimuli responsive delivery Translational nanomedicine Organ-focused pharmacology Clinical translation pathways