Tuning Autophagy-Inducing Activity and Toxicity for Lanthanide Nanocrystals
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Beschreibung
This thesis presents a simple, yet highly effective surface engineering solution that uses non-covalent binding peptides to control the autophagy-inducing activity of nanomaterials and nanodevices. The author presents RE-1, a short synthetic peptide that sequence-specifically binds to lanthanide (LN) oxide and upconversion nanocrystals with high affinity, which was discovered using an innovative phage display approach. RE-1 effectively inhibits the autophagy-inducing activity and toxicity of these nanocrystals by forming a stable coating layer on the surface of the nanoparticles, and by reducing their sedimentation and cell interaction. RE- 1 and its variants provide a versatile tool for tuning cell interactions in order to achieve the desired level of autophagic response and are useful for the various diagnostic and therapeutic applications of LN-based nanomaterials and nanodevices.
This thesis presents a simple, yet highly effective surface engineering solution that uses non-covalent binding peptides to control the autophagy-inducing activity of nanomaterials and nanodevices. The author presents RE-1, a short synthetic peptide that sequence-specifically binds to lanthanide (LN) oxide and upconversion nanocrystals with high affinity, which was discovered using an innovative phage display approach. RE-1 effectively inhibits the autophagy-inducing activity and toxicity of these nanocrystals by forming a stable coating layer on the surface of the nanoparticles, and by reducing their sedimentation and cell interaction. RE- 1 and its variants provide a versatile tool for tuning cell interactions in order to achieve the desired level of autophagic response and are useful for the various diagnostic and therapeutic applications of LN-based nanomaterials and nanodevices.
Nominated as a distinguished doctoral dissertation by the University of Science and Technology of China Describes new short synthetic peptide that sequence-specifically binds to lanthanide (LN) oxide based nanocrystals Demonstrates use of binding peptides to control the autophagy-inducing activity of nanomaterials and nanodevices Presents versatile tool for in vivo diagnostic imaging and therapeutic applications
Autor*in
Yunjiao Zhang
Themen in »Tuning Autophagy-Inducing Activity and Toxicity for Lanthanide Nanocrystals«
autophagy-inducing activity lanthanide (LN) nanocrystals phage display technology non-covalent binding peptides upconversion nanoparticles/nanocrystals (UCN) synthetic peptide RE-1 cell interaction and toxicity diagnostic and therapeutic applications