Role of Signaling Pathways in Brain Tumorigenesis
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Beschreibung
This book provides acomprehensive overview of cell signalling pathways and morphogens in the genesis of brain tumours. It also explains the role of brain tumour stem cells in the brain tumour progression. It also elucidates the novel early biomarkers that can be utilized to diagnose brain tumours. It presents the basic developmental pathways and morphogens, including retinoic acid and TGF-b that promote brain tumorigenesis. The chapters illustrate the role of stem cells and stem cells mediated cell signalling pathways including, Sonic hedgehog, Notch, Wnt in the brain tumour growth. The chapters also emphasize the role of transcription factors, mainlyNanog, Sox, BMI1, HIF1 and Pax6 in the brain tumouriogensis. It highlights the role of NF-kb, Myc and neurotrophins in the brain tumour development. Finally, the book summarizes the potential early therapeutic targets and targeted drug discovery for brain tumours.
This book provides acomprehensive overview of cell signalling pathways and morphogens in the genesis of brain tumours. It also explains the role of brain tumour stem cells in the brain tumour progression. It also elucidates the novel early biomarkers that can be utilized to diagnose brain tumours. It presents the basic developmental pathways and morphogens, including retinoic acid and TGF-b that promote brain tumorigenesis. The chapters illustrate the role of stem cells and stem cells mediated cell signalling pathways including, Sonic hedgehog, Notch, Wnt in the brain tumour growth. The chapters also emphasize the role of transcription factors, mainlyNanog, Sox, BMI1, HIF1 and Pax6 in the brain tumouriogensis. It highlights the role of NF-kb, Myc and neurotrophins in the brain tumour development. Finally, the book summarizes the potential early therapeutic targets and targeted drug discovery for brain tumours.
This book illustrates the details of origin of brain tumors and mechanism of progression It represents a comprehensive overview of the role of various cell signaling pathways in brain tumour development It illustrates the mechanism of pathway activation to tumor growth and therapeutic approach for brain tumor treatment
- This book illustrates the details of origin of brain tumors and mechanism of progression.2. - It represents a comprehensive overview of the role of various cell signaling pathways in brain tumour development. 3. - It illustrates the mechanism of pathway activation to tumor growth and therapeutic approach for brain tumor treatment
Autor*in
Mehdi Hayat Shahi
Themen in »Role of Signaling Pathways in Brain Tumorigenesis«
Brain Tumour Medulloblastoma Glioblastoma Sonic Hedgehog cell signaling Brain Tumour stem cells