Study on the Cellular Regulation and Function of Lysine Malonylation, Glutarylation and Crotonylation
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Beschreibung
This book presents pioneering findings on the characterization of cellular regulation and function for three recently identified protein posttranslational modifications (PTMs): lysine malonylation (Kmal), glutarylation (Kglu) and crotonylation (Kcr). It addresses three main topics: (i) Detecting Kmal substrates using a chemical reporter, which provides important information regarding the complex cellular networks modulated by Kmal; (ii) Identifying Kglu as a new histone PTM and assessing the direct impact of histone Kglu on chromatin structure and dynamics; and (iii) Revealing Sirt3’s value as a regulating enzyme for histone Kcr dynamics and gene transcription, which opens new avenues for examining the physiological significance of histone Kcr. Taken together, these studies provide information critical to understanding how these protein PTMs are associated with various human diseases, and to identifying therapeutic targets for the dysregulation of these novel protein markers in varioushuman diseases.
Nominated as an outstanding Ph.D. thesis by the University of Hong Kong Reports on important advances in the study of histone posttranslational modifications (PTMs) Introduces applications of the CLASPI approach in identifying ‘eraser’ enzymes for histone PTMs Discusses chemical reporters for protein posttranslational modifications Unravels the role of histone modifications in the regulation of chromatin structure
Autor*in
Xiucong Bao
Themen in »Study on the Cellular Regulation and Function of Lysine Malonylation, Glutarylation and Crotonylation«
Epigenetics Chemical Reporter Histone Posttranslational Modifications Chromatin Structure Protein-protein interaction Immunoblotting analysis Metabolic labeling Chemical proteomics approach Protein Structure Proteomics gene expression Cell Cycle Analysis