Cancer RNome: Nature & Evolution
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Beschreibung
In the last decade, researchers working in the field of cancer biology have shifted their focus from genetic defects to epigenetic dysregulation, especially that of non-coding RNAs (ncRNAs).
This book encompasses a comprehensive review of the transcriptional landscape of the cell and its involvement in the cancer pathophysiology. The first two chapters elucidate the basics of biosynthesis, mechanism of action and modulation of the epigenetic regulation of gene expression by coding as well as non-coding RNAs. The third chapter discusses the aberrant expression of the cellular RNome in the cancer cells and highlights its role in the orchestration of processes involved in evolution as well as the sustenance of cancer cells. The fourth chapter describes the recent advances in the field of translating the transcriptome into diagnostic/prognostic biomarkers and as targets for novel anti-cancer therapies. The final chapter then reviews the emerging experimental approaches to screen, identify and explore the functions of ncRNAs.
Providing valuable insights into the field of RNome in the context of cancer, this book is helpful to students, researchers and clinicians.In the last decade, researchers working in the field of cancer biology have shifted their focus from genetic defects to epigenetic dysregulation, especially that of non-coding RNAs (ncRNAs).
This book encompasses a comprehensive review of the transcriptional landscape of the cell and its involvement in the cancer pathophysiology. The first two chapters elucidate the basics of biosynthesis, mechanism of action and modulation of the epigenetic regulation of gene expression by coding as well as non-coding RNAs. The third chapter discusses the aberrant expression of the cellular RNome in the cancer cells and highlights its role in the orchestration of processes involved in evolution as well as the sustenance of cancer cells. The fourth chapter describes the recent advances in the field of translating the transcriptome into diagnostic/prognostic biomarkers and as targets for novel anti-cancer therapies. The final chapter then reviews the emerging experimental approaches to screen, identify and explore the functions of ncRNAs.Providing valuable insights into the field of RNome in the context of cancer, this book is helpful to students, researchers and clinicians..
The book discusses at length about the evolution of Cancer RNome Emphasis is given on how RNome reprograms the cellular energy metabolism and plays role in onset and maintenance of cancer Richly illustrated and easy to understand, the book covers all major areas of cancer RNomics
1. The book discusses at length about the evolution of Cancer RNome.
2. Emphasis is given on how RNome reprograms the cellular energy metabolism and plays role in onset and maintenance of cancer
3. Richly illustradted and easy to understand, the book covers all major areas of cancer RNomics
Autor*in
Mansi Arora
Themen in »Cancer RNome: Nature & Evolution«
Cancer Biology Cancer and RNome Non-coding RNAs Methylation addiction and chromatin remodeling Aerobic glycolysis