Targeting Protein-Protein Interactions by Small Molecules
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Beschreibung
This book comprehensively reviews the state-of-the-art strategies developed for protein-protein interaction (PPI) inhibitors, and highlights the success stories in new drug discovery and development. Consisting of two parts with twelve chapters, it demonstrates the design strategies and case studies of small molecule PPI inhibitors. The first part discusses various discovery strategies for small molecule PPI inhibitors, such as high throughput screening, hot spot-based design, computational approaches, and fragment-based design. The second part presents recent advances in small molecule inhibitors, focusing on clinical candidates and new PPI targets. This book has broad appeal and is of significant interest to the pharmaceutical science and medicinal chemistry communities.
Provides a comprehensive description of state-of-the-art strategies for the discovery of small molecule inhibitors of protein-protein interactions Highlights successful examples and the clinical development of small molecule inhibitors of protein-protein interactions Describes the recent advances in small molecule inhibitors acting on new targets Presents an in-depth discussion on the merits and limitations of various technologies and offers new perspectives to guide future research
Autor*in
Chunquan Sheng
Themen in »Targeting Protein-Protein Interactions by Small Molecules«
Protein-protein interactions Small molecule inhibitors Hot spots High throughput screening Fragment based drug discovery Secondary structure mimetics p53-MDM2 β Catenin/T-Cell Factor Keap1-Nrf2