Rethinking Platinum Anticancer Drug Design: Towards Targeted and Immuno-chemotherapeutic Approaches
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Beschreibung
This thesis describes the authors’ pioneering efforts in the conceptualization and implementation of combined platinum-based immuno-chemotherapeutics, which represent a significant paradigm shift from the conventional approach of directly targeting cancer. The work described has opened up a rich and largely unexplored area for platinum-based drug design, and ultimately paves the way for superior immuno-chemotherapeutics with better clinical outcome for patients. Historically, the contribution of the immune system to chemotherapy outcomes has been neglected, as anticancer drugs were believed to be immunosuppressive. However, this has been challenged by contemporary evidence suggesting that many chemotherapeutics, including platinum-based agents, stimulate the innate and/or adaptive immune system and that these “secret allies” contribute tangibly to clinical outcomes. A multi-pronged immuno-chemotherapeutic approach not only shrinks tumors, but more importantly, reactivate dormant immuneresponses to malignancies, eliminating residual cancer cells.
This thesis describes the authors’ pioneering efforts in the conceptualization and implementation of combined platinum-based immuno-chemotherapeutics, which represent a significant paradigm shift from the conventional approach of directly targeting cancer. The work described has opened up a rich and largely unexplored area for platinum-based drug design, and ultimately paves the way for superior immuno-chemotherapeutics with better clinical outcome for patients. Historically, the contribution of the immune system to chemotherapy outcomes has been neglected, as anticancer drugs were believed to be immunosuppressive. However, this has been challenged by contemporary evidence suggesting that many chemotherapeutics, including platinum-based agents, stimulate the innate and/or adaptive immune system and that these “secret allies” contribute tangibly to clinical outcomes. A multi-pronged immuno-chemotherapeutic approach not only shrinks tumors, but more importantly, reactivate dormant immuneresponses to malignancies, eliminating residual cancer cells.
Winner of the Wang Gungwu Award for the best PhD thesis in the Natural Sciences by the National University of Singapore (2016) Summarizes the pioneering efforts in the conceptualization and implementation of combined platinum-based immuno-chemotherapeutics Addresses a significant paradigm shift from the conventional approach of directly targeting cancer Explores a rich and largely unexplored domain for platinum-based drug design for superior immuno-chemotherapeutics
Autor*in
Daniel Yuan Qiang Wong
Themen in »Rethinking Platinum Anticancer Drug Design: Towards Targeted and Immuno-chemotherapeutic Approaches«
Immuno-Modulation by Platinum-based Complexes Chemoselective Imine Ligation Platinum(IV) Prodrugs Cisplatin Prodrugs HER2-Targeted Platinum(IV) Anticancer Prodrugs Multimodal Anticancer Agents Chemotherapeutic Platinum Complexes Platinum(IV)-Peptide Conjugates Platinum(IV) Prodrug Scaffold Targeted Necrosis