New Carbon–Carbon Coupling Reactions Based on Decarboxylation and Iron-Catalyzed C–H Activation
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Beschreibung
This thesis presents the latest developments in new catalytic C–C bond formation methods using easily accessible carboxylate salts through catalytic decarboxylation with good atom economy, and employing the sustainable element iron as the catalyst to directly activate C–H bonds with high step efficiency. In this regard, it explores a mechanistic understanding of the newly discovered decarboxylative couplings and the catalytic reactivity of the iron catalyst with the help of density functional theory calculation.
The thesis is divided into two parts, the first of which focuses on the development of a series of previously unexplored, inexpensive carboxylate salts as useful building blocks for the formation of various C–C bonds to access valuable chemicals. In turn, the second part is devoted to several new C–C bond formation methodologies using the most ubiquitous transition metal, iron, as a catalyst, and using the ubiquitous C–H bond as the coupling partner.
This thesis presents the latest developments in new catalytic C–C bond formation methods using easily accessible carboxylate salts through catalytic decarboxylation with good atom economy, and employing the sustainable element iron as the catalyst to directly activate C–H bonds with high step efficiency. In this regard, it explores a mechanistic understanding of the newly discovered decarboxylative couplings and the catalytic reactivity of the iron catalyst with the help of density functional theory calculation.
The thesis is divided into two parts, the first of which focuses on the development of a series of previously unexplored, inexpensive carboxylate salts as useful building blocks for the formation of various C–C bonds to access valuable chemicals. In turn, the second part is devoted to several new C–C bond formation methodologies using the most ubiquitous transition metal, iron, as a catalyst, and using the ubiquitous C–H bond as the coupling partner.
Nominated as an outstanding PhD thesis by the University of Science and Technology of China Highlights a series of highly efficient decarboxylative coupling reactions that will be of interest to synthetic chemists Presents several inexpensive and user-friendly carboxylate salts that offer useful coupling reagents to access valuable chemicals, including drug intermediates Explores the unknown reactivity of iron as a catalyst and presents step-efficient C–H coupling reactions to form C–C bonds using the sustainable catalyst iron Winner of the Chinese Academy of Sciences 100 Excellent Doctoral Dissertation Award (2015) Includes supplementary material: sn.pub/extras
Autor*in
Rui Shang
Themen in »New Carbon–Carbon Coupling Reactions Based on Decarboxylation and Iron-Catalyzed C–H Activation«
Metal catalysis C-C bond formation Decarboxylation Palladium-catalyzed decarboxylative coupling Carboxylate salts Iron-catalyzed C-H ativation Copper-catalyzed decarboxylative coupling C-H functionalization