Proteases in Physiology and Pathology

Beschreibung

Using a multidisciplinary approach, this book describes the biochemical mechanisms associated with dysregulation of proteases and the resulting pathophysiological consequences. It highlights the role and regulation of different types of proteases as well as their synthetic and endogenous inhibitors. The role of proteases was initially thought to be limited to general metabolic digestion. However, we now know that the role of protein breakdown is much more complex, and proteases have multiple functions: they are coupled to turnover and can affect protein composition, function and synthesis. In addition to eliminating abnormal proteins, breakdown has many modulatory functions, including activating and inactivating enzymes, modulating membrane function, altering receptor channel properties, affecting transcription and cell cycles and forming active peptides. The ubiquity of proteases in nature makes them an important target for drug development.

This in-depth, comprehensive is avaluable resource for researchers involved in identifying new targets for drug development. With its multidisciplinary scope, it bridges the gap between fundamental and translational research in the biomedical and pharmaceutical industries, making it thought-provoking reading for scientists in the field.

Offers a comprehensive investigation into the regulation of proteases and their pathological consequences

Explores the specific inhibitors and molecular probes for proteases to improve therapy for various diseases

Serves as valuable resource for those involved in improving protease-targeted therapeutic approaches of life-threatening diseases

Autor*in

Sajal Chakraborti

Themen in »Proteases in Physiology and Pathology«

Protease and Antiproteases Neuronal Diseases Cancer Cardiovascular Diseases Parasitic Diseases Gene Therapy

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