Frontiers of Biostatistical Methods and Applications in Clinical Oncology
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Beschreibung
This book presents the state of the art of biostatistical methods and their applications in clinical oncology. Many methodologies established today in biostatistics have been brought about through its applications to the design and analysis of oncology clinical studies. This field of oncology, now in the midst of evolution owing to rapid advances in biotechnologies and cancer genomics, is becoming one of the most promising disease fields in the shift toward personalized medicine. Modern developments of diagnosis and therapeutics of cancer have also been continuously fueled by recent progress in establishing the infrastructure for conducting more complex, large-scale clinical trials and observational studies. The field of cancer clinical studies therefore will continue to provide many new statistical challenges that warrant further progress in the methodology and practice of biostatistics. This book provides a systematic coverage of various stages of cancer clinical studies. Topics from modern cancer clinical trials include phase I clinical trials for combination therapies, exploratory phase II trials with multiple endpoints/treatments, and confirmative biomarker-based phase III trials with interim monitoring and adaptation. It also covers important areas of cancer screening, prognostic analysis, and the analysis of large-scale molecular data in the era of big data.
This book presents the state of the art of biostatistical methods and their applications in clinical oncology. Many methodologies established today in biostatistics have been brought about through its applications to the design and analysis of oncology clinical studies. This field of oncology, now in the midst of evolution owing to rapid advances in biotechnologies and cancer genomics, is becoming one of the most promising disease fields in the shift toward personalized medicine. Modern developments of diagnosis and therapeutics of cancer have also been continuously fueled by recent progress in establishing the infrastructure for conducting more complex, large-scale clinical trials and observational studies. The field of cancer clinical studies therefore will continue to provide many new statistical challenges that warrant further progress in the methodology and practice of biostatistics. This book provides a systematic coverage of various stages of cancer clinical studies. Topics from modern cancer clinical trials include phase I clinical trials for combination therapies, exploratory phase II trials with multiple endpoints/treatments, and confirmative biomarker-based phase III trials with interim monitoring and adaptation. It also covers important areas of cancer screening, prognostic analysis, and the analysis of large-scale molecular data in the era of big data.
Presents the state of the art of biostatistics in clinical oncology, covering various topics from design and analysis of modern clinical trials, disease screening, prognostic analysis, and analysis of large-scale molecular data Is written by experts in biostatistical methodology and practice in cancer clinical studies Sets forth an effective balance between biostatistical methodology and practice Includes supplementary material: sn.pub/extras
Autor*in
Shigeyuki Matsui
Themen in »Frontiers of Biostatistical Methods and Applications in Clinical Oncology«
Biostatistics Cancer Clinical Trials Clinical Oncology Design and Analysis of Clinical Trials Statistical Analysis of Omics Data
Stimmen zu »Frontiers of Biostatistical Methods and Applications in Clinical Oncology«
“I strongly recommend that those statisticians working in the clinical oncology field check out these articles. Several were of use to me and I know that others will find them to be of use as well.” (David E. Booth, Technometrics, Vol. 60 (3), 2018)
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