Identification of Ligand Binding Site and Protein-Protein Interaction Area
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Beschreibung
This volume presents a review of the latest numerical techniques used to identify ligand binding and protein complexation sites. It should be noted that there are many other theoretical studies devoted to predicting the activity of specific proteins and that useful protein data can be found in numerous databases. The aim of advanced computational techniques is to identify the active sites in specific proteins and moreover to suggest a generalized mechanism by which such protein-ligand (or protein-protein) interactions can be effected.
Developing such tools is not an easy task – it requires extensive expertise in the area of molecular biology as well as a firm grasp of numerical modeling methods. Thus, it is often viewed as a prime candidate for interdisciplinary research.
This volume presents a review of the latest numerical techniques used to identify ligand binding and protein complexation sites. It should be noted that there are many other theoretical studies devoted to predicting the activity of specific proteins and that useful protein data can be found in numerous databases. The aim of advanced computational techniques is to identify the active sites in specific proteins and moreover to suggest a generalized mechanism by which such protein-ligand (or protein-protein) interactions can be effected. Developing such tools is not an easy task – it requires extensive expertise in the area of molecular biology as well as a firm grasp of numerical modeling methods. Thus, it is often viewed as a prime candidate for interdisciplinary research.
Comparative analysis of models based on geometry versus those based on knowledge of the biological phenomenon Application note Relation to biological phenomena All illustrations in full color A review of the latest numerical techniques used to identify ligand binding and protein complexation sites
Autor*in
Irena Roterman-Konieczna
Themen in »Identification of Ligand Binding Site and Protein-Protein Interaction Area«
bioinformatics ligand binding protein-protein complexation structure of proteins