Central Nervous System Metastasis, the Biological Basis and Clinical Considerations
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Beschreibung
This volume covers what is known regarding the natural history, basic biology, and clinical aspects, including imaging and treatment, of CNS metastasis. Three chapters cover the biology of the brain and brain metastases: molecular biology, includes what is known about specific genes/proteins involved in the process of metastasis and model systems to study brain metastasis; brain microenvironment, focuses on the resident cells of the microenvironment and their role in CNS metastasis; and the blood-brain barrier, includes a discussion of permeability with respect to brain metastases. A discussion of experimental imaging covers both the biology of brain metastasis from an imaging perspective and the use of imaging techniques to study brain metastases. The three clinical chapters discuss treatment options of surgery, chemotherapy, and radiation. The potential for novel targeted therapies is also addressed. Because of the uniqueness of the disease, leptomeningeal metastasis is discussedseparately. The last chapter is devoted to quality of life issues associated with CNS metastasis.
This volume will cover what is known regarding the biology and treatment of CNS metastasis, including novel chapters such as the future of targeted therapies. It will begin with an overview of the natural history and risk factors for CNS metastases that will broadly cover all cancer histologies. This will be followed by 3 chapters that will cover the biology. These include: molecular biology, discussing what is known about specific genes/proteins involved in the process and model systems to study brain metastasis; the brain microenvironment, focusing on how it is different from the microenvironment of other organs of the body; and the blood-brain barrier, which includes a discussion of permeability with respect to brain metastases. A chapter on experimental imaging will cover both the biology of brain metastasis from an imaging perspective and use of imaging techniques to study brain metastases. The clinical chapters will discuss treatment options with separate chapters on surgery, chemotherapy and radiation. In addition, leptomeningeal metastasis will be given its own chapter. Finally, quality of life issues will be the concluding chapter.
Comprehensive resource of both biology and clinical knowledge of CNS metastasis Only current book to cover the biology in depth, most cover clinical management of the disease Topics covered by leaders in their respective fields
Autor*in
Diane Palmieri
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Biology Brain CNS Metastasis Metastasis
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From the reviews:
“This book reviews both the biology of central nervous system metastases and the basics of diagnosis and management. … The audience for this book is broad, in that it may attract both basic scientists and the clinicians. … the book is well written and easy to understand. … This is a book that I would value in my personal library. … I have not seen a book in this field with a similar breadth in covering both a scientific and clinical overview of CNS metastases.” (Priya U. Kumthekar, Doody’s Book Reviews, July, 2013)()