Endotoxins: Structure, Function and Recognition
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Beschreibung
Endotoxins are potentially toxic compounds produced by Gram-negative bacteria including some pathogens. Unlike exotoxins, which are secreted in soluble form by live bacteria, endotoxins are comprised of structural components of bacteria.
Endotoxins can cause a whole-body inflammatory state, sepsis, leading to low blood pressure, multiple organ dysfunction syndrome and death.
This book brings together contributions from researchers in the forefront of these subjects. It is divided into two sections. The first deals with how endotoxins are synthesized and end up on the bacterial surface. The second discussed how endotoxins activate TLR4 and, in turn, how TLR4 generates the molecular signals leading to infectious and inflammatory diseases.
The way endotoxins interact with the host cells is fundamental to understanding the mechanism of sepsis, and recent research on these aspects of endotoxins has served to illuminate previously undescribed functions of the innate immune system. This volume presents a description of endotoxins according to their genetic constitution, structure, function and mode of interaction with host cells.
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Gives new insights into the role of the innate immune system in infection by gram-negative bacteria Presents a description of endotoxins according to their biosynthesis, genetic constitution, structure, function and mode of interaction with host cells Brings together contributions from researchers in the forefront of endotoxin research Provides fundamental understanding of the mechanism behind whole-body inflammation or sepsis.
Autor*in
Xiaoyuan Wang
Themen in »Endotoxins: Structure, Function and Recognition«
Antigen Sepsis bacteria infection infectious vaccine infectious diseases
Stimmen zu »Endotoxins: Structure, Function and Recognition«
From the reviews:
“The book consists of two parts that include 17 chapters prepared by an international team of well_ known experts. … The book is well prepared. There are many good quality photos, graphs, and pictures. Each chapter ends with a base reference, and there is a subject index at the end of the book. … very useful for many researchers in the field of biochemistry, biotechnology, immunology, and medicinal chemistry. This book can also be a useful tool for teachers and students of colleges and universities.” (G. Ya. Wiederschain, Biochemistry, Vol. 76 (5), May, 2011)()