Adverse Events with Biomedicines
Prevention Through Understanding
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Beschreibung
This monograph gathers and evaluates data on adverse events (AEs) associated specifically with those “biomedicines” – monoclonal antibodies, fusion proteins, and cytokines – that have recently entered therapeutic use in humans. All AEs observed when using each member of this new drug class are covered, with a view to improving understanding of pathogenesis, facilitating prevention, monitoring, and control, and contributing to the development of better drugs that provide benefits while minimizing risk. Further aspects here examined include the role of drug mechanisms of action and immunogenicity in relation to AEs outcome and induction of systemic syndromes. Additional data on AEs in off-label treatments are also considered.
Electronic data sheets, downloadable from the Springer Extra Materials platform, include more detailed safety data as well as additional basic information on product characteristics, pre- and post-marketing AEs classified according to frequency, and system/organ targeting. Data on excipients and selected information on drug interactions and associations are also provided. Adverse Events with Biomedicines: Prevention Through Understanding will serve as a detailed, practical guideline to this important new area, which demands the attention of clinicians, immunologists, oncologists, allergologists, public health professionals, and drug companies.
This monograph gathers and evaluates data on adverse events (AEs) associated specifically with those “biomedicines” – monoclonal antibodies, fusion proteins, and cytokines – that have recently entered therapeutic use in humans. All AEs observed when using each member of this new drug class are covered, with a view to improving understanding of pathogenesis, facilitating prevention, monitoring, and control, and contributing to the development of better drugs that provide benefits while minimizing risk. Further aspects here examined include the role of drug mechanisms of action and immunogenicity in relation to AEs outcome and induction of systemic syndromes. Additional data on AEs in off-label treatments are also considered.Electronic data sheets, downloadable from Springer Extra Materials platform, include more detailed safety data as well as additional basic information on product characteristics, pre- and post-marketing AEs classified according to frequency, and system/organ targeting. Data on excipients and selected information on drug interactions and associations are also provided. Adverse Events with Biomedicines: Prevention Through Understanding will serve as a detailed, practical guideline to this important new area, which demands the attention of clinicians, immunologists, oncologists, allergologists, public health professionals, and drug companies.
Synthetic and unique publication on adverse events of a new and fast-growing class of medicines Multidisciplinary interest (biomedical, public health, biologics producers for human therapy) Downloadable data sheets enclosed for rapid multi-entry search and consultation? Includes supplementary material: sn.pub/extras
Autor*in
Giuseppe Tridente
Themen in »Adverse Events with Biomedicines«
Adverse events (AEs) Antireceptor biologics Biomedicines or biologics Cytokines Fusion proteins Monoclonal antibodies (moAbs) Safety profiles Soluble receptor analogs
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From the reviews:
“This is a comprehensive review of existing biological therapeutics and their associated toxicities. … This is a thorough and detailed book, written for experts. … this book is more suitable for researchers in this area and for individuals involved in the regulation or testing of biological drugs. … This is a unique source of detailed information on biological drugs. I would recommend it to anyone interested in this field of research.” (Mitchell R. McGill, Doody’s Book Reviews, March, 2014)()