Thyroid and Heart Failure
From Pathophysiology to Clinics
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Beschreibung
Both thyroid dysfunction and heart failure show a high prevalence in the adult population. Frequently, in clinical practice, a multidisciplinary approach is useful to optimize the management of patients with these conditions. Although there is no doubt regarding the close link between cardiovascular pathophysiology and thyroid homeostasis, our understanding of this association is far from being exhaustive. Thyroid hormone regulates the expression of cardiac-specific functional contractile and structural proteins and plays a pivotal role in modulating both diastolic and systolic function as well as peripheral vascular resistance. The close relationship between thyroid and heart dysfunction is strongly supported by recent evidence demonstrating that an altered thyroid profile is a negative prognostic predictor in patients with heart failure. The treatment of chronic heart failure, especially in advanced stages of the disease, continues to be an open and challenging field. The potential of novel thyroid hormone therapies that address the molecular biology of thyroid dysfunction and heart failure thus represents an attractive area of multidisciplinary scientific interest. This book is a readable, integrated, and highly up to date presentation of the clinical, pathophysiological, and basic science aspects of thyroid–heart failure interactions. It addresses a complex subject in an approach that targets a large audience of readers.
Both thyroid dysfunction and heart failure show a high prevalence in the adult population. Frequently, in clinical practice, a multidisciplinary approach is useful to optimize the management of patients with these conditions. Although there is no doubt regarding the close link between cardiovascular pathophysiology and thyroid homeostasis, our understanding of this association is far from being exhaustive. Thyroid hormone regulates the expression of cardiac-specific functional contractile and structural proteins and plays a pivotal role in modulating both diastolic and systolic function as well as peripheral vascular resistance. The close relationship between thyroid and heart dysfunction is strongly supported by recent evidence demonstrating that an altered thyroid profile is a negative prognostic predictor in patients with heart failure. The treatment of chronic heart failure, especially in advanced stages of the disease, continues to be an open and challenging field. The potential of novel thyroid hormone therapies that address the molecular biology of thyroid dysfunction and heart failure thus represents an attractive area of multidisciplinary scientific interest. This book is a readable, integrated, and highly up to date presentation of the clinical, pathophysiological, and basic science aspects of thyroid–heart failure interactions. It addresses a complex subject in an approach that targets a large audience of readers.
Volume describes the relationship between the altered thyroid hormone profile and the prognosis of patients with heart failure, a novel and controversial issue of interest for all the medical community Also describes the new, emerging therapeutical strategies for heart failure, based on modulation of thyroid hormone Includes supplementary material: sn.pub/extras
Autor*in
Giorgio Iervasi
Themen in »Thyroid and Heart Failure«
Bypass cardiac function cardiovascular heart homeostasis hormone hormone receptors molecular biology pathophysiology physiology receptor signaling surgery therapy thyroid hormone treatment
Stimmen zu »Thyroid and Heart Failure«
From the reviews:
"This book presents contributions from preeminent scientists, both bench and clinical, to summarize the important interplay between the failing heart and the thyroid gland. This book attempts to gather the most up-to-date information about the pathophysiological and clinical significance of thyroid disease in relationship to heart failure. Students, physicians in training, and clinicians involved in the management of heart failure patients are the intended readers. … This is a well designed book for caregivers whose primary focus is heart failure." (David J. Homan, Doody’s Review Service, September, 2009)
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