Photoaffinity Labeling for Structural Probing Within Protein
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Beschreibung
This book covers the most up-to-date photoaffinity labeling method to tackle the key loop module involved in the binding process of a bioactive small molecule to its host protein. The book introduces rational points for preparing powerful photoaffinity probes, keys for the efficient analysis of labeled products, and recent successful applications for protein probing. Regarding drug design, the unique topics of the book are the special consideration of the crosslinking potential of recent probes and their application of important receptor proteins . This book presents emerging technologies of photoaffinity labeling to readers who are working in the fields of proteomics, molecular recognition, and drug discovery and development.
Provides a reliable strategy to probe molecular targets during the early stages of drug discovery and development
Describes the potential of updated photoaffinity labeling among chemical methods for the structural elucidation of proteins
Clarifies the chemical biology for the design and development of high-performance photoaffinity probesProvides a reliable strategy to probe molecular targets during the early stages of drug discovery and development Describes the potential of updated photoaffinity labeling among chemical methods for the structural elucidation of proteins Clarifies the chemical biology for the design and development of high-performance photoaffinity probes
Autor*in
Yasumaru Hatanaka
Themen in »Photoaffinity Labeling for Structural Probing Within Protein«
Protein analysis Affinity-based profiling Membrane protein Bioactive molecule Ligand receptor Molecular recognition Binding site Photoactivatable probe Multifunctional probe Diazirine Carbene Cross-linking Drug discovery Chemical biology biochemical engineering