Iron-Catalyzed Synthesis of Fused Aromatic Compounds via C–H Bond Activation
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Beschreibung
Iron catalysts in organic synthesis are strongly in demand because iron is non-toxic, inexpensive, and the most abundant transition metal in the earth, although their use is still limited compared with that of rare, precious metals such as palladium, ruthenium, and rhodium. This thesis describes the first practical example of iron catalysis in the carbon–hydrogen bond activation reaction to synthesized fused aromatic ring compounds. By using a unique combination of iron catalyst and dichloride oxidant, various kind of naphthalene and phenanthrene derivatives were synthesized via annulation reaction with alkynes including direct C–H bond activation process. This achievement opens the new possibility of low-valent iron catalysis and expands synthetic methods for a sustainable society.
Iron catalysts in organic synthesis are strongly in demand because iron is non-toxic, inexpensive and the most abundant transition metal in the earth, although their use is still limited compared with that of rare, precious metals such as palladium, ruthenium and rhodium. This thesis describes the first practical example of iron catalysis in the carbon–hydrogen bond activation reaction to synthesized fused aromatic ring compounds. By using a unique combination of iron catalyst and dichloride oxidant, various kind of naphthalene and phenanthrene derivatives were synthesized via annulation reaction with alkynes including direct C–H bond activation process. This achievement opens the new possibility of low-valent iron catalysis and expands synthetic methods for a sustainable society.
Nominated by The University of Tokyo as an outstanding Ph.D. thesis Provides examples of C-H bond activation which has attracted attention as an important chemical reaction in organic chemistry Shows researchers how to develop a new reactivity of iron that is not only a simple alternative to rare metals Includes supplementary material: sn.pub/extras
Autor*in
Arimasa Matsumoto
Themen in »Iron-Catalyzed Synthesis of Fused Aromatic Compounds via C–H Bond Activation«
Alkyne Annulation C–H Bond Activation Fused Aromatic Compounds Iron Catalysis Iron Catalyst Naphthalene Derivatives Phenanthrene Derivatives