Mapping QTL Affecting Growth and Body Composition in Chicken Using Genome-Wide Linkage Analyses
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Beschreibung
Growth-related traits and in particular the yield of muscle mass and the amount of white adipose tissue deposition in the body are the most important traits that influence the nutritional and economic value of a chicken. Intramuscular fat content contributes to meat quality. Therefore, it is desirable for chicken breeders to know the genetic determinants of these traits to use the information for genetic improvement of meat production and effective growth. The aims of this thesis were to map genomic regions affecting several growth-related traits and estimate genetic effects of identified regions.
In conclusion of the obtained results and because of the large phenotypic effects of several QTL regions, I suggest physical dissection of the QTL regions on GGA2, 4 and 27 and subsequent genes targeting. This can be performed by repeated back-crossing of recombinant QTL interval to one of the parental lines or the generation of advanced-intercross lines. The combined analysis of different crosses in which QTL were found in the same genomic region could also be used to find shorter haplotypes that account for the observed effects. The final identification of genes will contribute to our understanding of the complex inheritance pattern of growth regulation, muscle development and fat deposit in chicken.
Autor*in
Mostafa Kamal Khalil Nassar
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