Fetal origins of pediatric disease

Beschreibung

Improving child health worldwide is a core public health objective, identifying the risk factors of child disease an important research priority. This book presents a series of five human studies unraveling two common risk factors that operate as early as during intrauterine life: stress during pregnancy and synthetic glucocorticoids commonly used in reproductive medicine. The findings provide evidence that stress during pregnancy predicts placental and fetal growth, and is associated with an increased disease risk in the offspring during childhood. They further suggest that therapy with synthetic glucocorticoids during pregnancy may result in disturbed endocrinology throughout offspring childhood. A framework introduces the reader into the public health perspective and scientific background of the work, and guides the integration of the presented findings by a concluding comprehensive discussion with regard to implications for future research, clinical practice and policy. The findings contribute to a better understanding of the fetal origins of pediatric disease.

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Marion Tegethoff

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