Insights into protein dynamics by time-resolved X-ray scattering
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Beschreibung
Rohit Jain, born 1983 in Delhi, India, performed his PhD thesis at Max Planck Institute for Biophysical Chemistry, Goettingen from 2011 until 2015. The goal was to reach a better understanding of protein dynamics with time-resolved X-ray scattering technique.
It was achieved by working on three complementary themes. They are viz., (a) to develop a new real-time 20-microchannelrapid-mixing time-resolved small-angle X-ray scattering (TR-SAXS) method; to investigate the early millisecond steps of ubiquitin unfolding and to quantitatively describe the transient ubiquitin unfolding ensembles by using this novel methodology; (b) to obtain insights into the conformational structural dynamics of the enzymatic cycle of human guanylate kinase (hGMPK) with X-ray scattering and (c) laser pump-X-ray scattering probe experiments to probe ubiquitin dynamics on picosecond to millisecond timescale.
Autor*in
Rohit Jain
Themen in »Insights into protein dynamics by time-resolved X-ray scattering«
Biocatalysis, Ubiquitin Equilibrium small-angle-ray scattering Human Guanylate Kinase Microfluidics Protein Dynamics Protein folding-unfolding Pump-probe X-ray scattering, Structural Dy Time-resolved small-angle X-ray scattering Y-ray syncrotrons