Regulation and function of host cell miRNAs upon Helicobacter pylori infection
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Beschreibung
Helicobacter pylori is a human pathogen infecting ~50% of the world´s population. H. pylori´s main ecological niche is the human stomach. Chronic infections with H. pylori can induce peptic ulcer disease (10-20% of infected people), and two kinds of tumors are epidemiologically strongly connected to the H. pylori infection, the gastric adenocarcinoma (1-2%) and the gastric mucosaassociated lymphatic tissue (MALT) lymphoma (~0.1%). The severity and occurrence of the H. pylori related gastric diseases are highly linked to the expression of the cag pathogenicity island (cagPAI). However, H. pylori induced carcinogenesis is not completely understood. A recently identified novel class of small RNAs called microRNA (miRNA) was shown to be an important player in mammals for the development of inflammation and cancer. The aim of this thesis was to identify H. pylori regulated host cell miRNAs and to determine biological functions of these miRNAs upon H. pylori infection.
Helicobacter pylori is a human pathogen infecting ~50% of the world´s population. H. pylori´s main ecological niche is the human stomach. Chronic infections with H. pylori can induce peptic ulcer disease (10-20% of infected people), and two kinds of tumors are epidemiologically strongly connected to the H. pylori infection, the gastric adenocarcinoma (1-2%) and the gastric mucosaassociated lymphatic tissue (MALT) lymphoma (~0.1%). The severity and occurrence of the H. pylori related gastric diseases are highly linked to the expression of the cag pathogenicity island (cagPAI). However, H. pylori induced carcinogenesis is not completely understood. A recently identified novel class of small RNAs called microRNA (miRNA) was shown to be an important player in mammals for the development of inflammation and cancer. The aim of this thesis was to identify H. pylori regulated host cell miRNAs and to determine biological functions of these miRNAs upon H. pylori infection.
Autor*in
Manuel Koch
Themen in »Regulation and function of host cell miRNAs upon Helicobacter pylori infection«
Helicobacter pylori gastric adenocarcinoma gastric mucosaassociatedlymphatic tissue peptic ulcerdisease tumor