Pharmacokinetic/pharmacodynamic-guided optimisation of monoclonal antibody therapy in special populations
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Beschreibung
Monoclonal antibodies constitute a therapeutically and economically important drug class, evident by the growing number on the market and in drug development. Still, sub-optimal use of monoclonal antibodies can result in loss of response or adverse events. In this thesis, pharmacometric modelling and simulation methodologies were applied to contribute to the pharmacokinetic/pharmacodynamic understanding of monoclonal antibodies in two populations, namely children and patients with Crohn's disease.
Autor*in
Helena Edlund
Themen in »Pharmacokinetic/pharmacodynamic-guided optimisation of monoclonal antibody therapy in special populations«
Crohn's disease PK/PD processes of mAbs anti-drug antibodies clinical pharmacy infliximab mAbs monoclonal antibodies