Transition to Turbulence in Physiological Flows: Direct Numerical Simulation of Hemodynamics in Intracranial Aneurysms and Cerebrospinal Fluid Hydrodynamics in the Spinal Canal
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Beschreibung
The advent of supercomputers has made it possible to simulate physiological flows and improve understanding of pathology and pathophysiology of various diseases. Physiological flows, in spite of low Reynolds number (< 500), are known to exhibit turbulent like activity. This thesis investigates the onset of flow-transition in blood flow in intracranial aneurysms and the cerebrospinal fluid (CSF) flow in the spinal canal by conducting numerical simulations using the Lattice Boltzmann Method (LBM) in subject specific cases.
The first part of the thesis describes the basics of transitional flows and the LBM. The methodology is validated by simulating transition in pulsatile stenotic flows and comparing the results against literature. The work is then extended to explore transition in oscillatory flow.
The second part elaborates the prevalence and pathophysiology of intracranial aneurysms and reports simulations of transitional hemodynamics in aneurysms. The morphological and fluid dynamical aspects that lead to flow-transition in aneurysms and its clinical implications are discussed.
The third part describes pathology and pathophysiology of the CSF and presents simulations of CSF flow in the subarachnoid space of one healthy subject and two Chiari I patients. Clinical implications of transitional CSF hydrodynamics are discussed in detail.
Autor*in
Kartik Jain
Themen in »Transition to Turbulence in Physiological Flows: Direct Numerical Simulation of Hemodynamics in Intracranial Aneurysms and Cerebrospinal Fluid Hydrodynamics in the Spinal Canal«
Intracranial Aneurysm Lattice Boltzmann Method Transition to Turbulence