Population Pharmacokinetic Modelling and Simulation of Monoclonal Antibodies Including the Impact of Immunogenicity and Importance of Study and Analysis Design Factors

Beschreibung

In the present thesis, pharmacometric modelling methodologies were applied to determine the pharmacokinetics of sibrotuzumab, a humanised therapeutic monoclonal antibody, and to account for the in uence of immunogenicity. Furthermore, design factors in uencing the identi ability of model parameters characterising monoclonal antibody pharmacokinetics were investigated using a simulation-based approach.

Autor*in

Ronald Niebecker

Themen in »Population Pharmacokinetic Modelling and Simulation of Monoclonal Antibodies Including the Impact of Immunogenicity and Importance of Study and Analysis Design Factors«

immunogenicity monoclonal antibodies pharmacometrics

Stimmen zu »Population Pharmacokinetic Modelling and Simulation of Monoclonal Antibodies Including the Impact of Immunogenicity and Importance of Study and Analysis Design Factors«

Details

Link teilen