Controlling Quality and Kinetics of Drying Processes for Amorphous Solid Dispersions

Beschreibung

The present thesis investigates the drying of amorphous solid dispersions (ASDs) composed of PVPVA64 and indomethacin from ethanol–water solutions. Thermodynamic modeling based on the Perturbed-Chain Statistical Associating Fluid Theory (PC-SAFT) was employed to identify suitable feed compositions that remain homogeneous throughout the entire drying process. Furthermore, a novel modeling approach was developed to describe the drying kinetics of ASD solutions. Based on single-solvent drying data of the pure polymer, the model enables reliable prediction of drying kinetics in mixed-solvent systems, showing very good agreement with experimental results. Following primary drying, the removal of residual solvent during secondary drying represents a significant challenge due to strongly hindered diffusion in glassy ASDs. To enhance secondary drying, a water-assisted drying strategy at constant relative humidity was investigated. Using the non-equilibrium extension of PC-SAFT, both the compositional evolution during secondary drying and the optimal relative humidity for efficient ethanol removal were predicted and experimentally validated.

Autor*in

Jana Kerkhoff

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Amorphous Solid Dispersions Drying Kinetics Secondary Drying

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