Innovative downstream concept for di-carboxylic acids of biocatalytic origin
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Beschreibung
Di-carboxylic acids of biocatalytic origin have a high potential as bio-based platform chemicals within the chemical industry. The biocatalytic production of di-carboxylic acids via fermentation has improved significantly within the last decade. The bottleneck to overcome is the search for an ecological and economical downstream processing of di-carboxylic acids.
Reactive extraction as an innovative approach for the initial product recovery within a downstream concept is the method of choice to overcome this bottleneck within this thesis. The di-carboxylic acids cis,cis-muconic acid and itaconic acid were chosen as representatives due to their high potential in the chemical industry.
Following a systematic approach for every single process step, the reactive extraction of di-carboxylic acids is embedded into a downstream concept, consisting of a bio-compatible reactive extraction as the initial product recovery step (conversion rates of > 0.90), a back-extraction via addition of a second reactive component (water-soluble mono-nitrogen amine allowing full recovery) and a final purification process via evaporation-based crystallization, leading to solid di-carboxylic acid of highest purity. Additionally, the reactive extraction and back-extraction are transferred into a continuous process mode to demonstrate the potential of the downstream concept within an industrial application.
The last important step of this thesis is the application of the downstream concept onto a fermentation system. First, the influence of the single components of the fermentation system onto the reactive extraction is investigated in detail to optimize the production process in an integrated approach. The results of this study allow for a reactive extraction of itaconic acid from a fermentation system with an extraction yield of ≥ 0.90, resulting in itaconic acid of biocata-lytic origin of highest purity.
This work is the proof, that the reactive extraction enables the purification of di-carboxylic acids of biocatalytic origin in highest purity at best yields directly from a fermentation system.
Autor*in
Jannick Gorden
Themen in »Innovative downstream concept for di-carboxylic acids of biocatalytic origin«
Reactive extraction Innovative downstream processing Di-carboxylic acid