The Construction of Analogy-Based Research Programs
The Lock-and-Key Analogy in 20th Century Biochemistry
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Beschreibung
By reconstructing the history of the lock-and-key analogy in fields of biochemistry and molecular biology, this book reveals new aspects of the mutual interactions between analogy usage, model building and research development.
When the German chemist Emil Fischer presented his lock-and-key hypothesis in 1899, his analogy to describe the molecular relationship between enzymes and substrates quickly gained vast influence and provided future generations of scientists with a tool to investigate the relation between chemical structure and biological specificity.Rebecca Mertens explains the appeal of the lock-and-key analogy by its role in model building and in the construction of long-term, cross-generational research programs. She argues that a crucial feature of these research programs, namely ascertaining the continuity of core ideas and concepts, is provided by a certain way of analogy-based modelling.
Autor*in
Rebecca Mertens
Themen in »The Construction of Analogy-Based Research Programs«
Lock-key Hypothesis Lock-key Hypothesis Analogy Analogy Research Program Research Program Molecular Biology Molecular Biology Biochemistry Biochemistry History of Science History of Science Science Science Medicine