Der Einfluss kurz- und mittelkettiger Fettsäuren auf die mitochondriale Funktion in akuter Entzündung

Beschreibung

Sepsis is a critical disease known as a severe inflammatory disorder which is characterized by an inadequate inflammatory response of the organism to a pathogen leading to a massive activation and production of further proinflammatory cytokines. Sepsis is associated with high mortality in intensive care units mostly due to multiorgan failure. Mitochondrial dysfunction leading to a severe decline in cellular energy supply, aggravating cell death and apoptosis, plays a key role in the pathophysiology of this disease. The aim of this work was to show whether the application of short- and medium chain fatty acids might improve mitochondrial function under inflammatory conditions and thus might serve as a potential energy source. In an experimental approach cellular respiration of starved human umbilical endothelial cells and peripheral monocytes under incubation with hexanoic acid, heptanoic acid, octanoic acid and glucose was examined. Under high resolution respirometry cellular respiration and thus mitochondrial function in a real time experiment was assessed. In a second set of experiments human umbilical endothelial cells and monocytes were treated with tumor necrosis factor- to mimic inflammatory conditions. The results showed that the application of short- and medium chain fatty acids increased mitochondrial respiration capacity in both cell lines at baseline as well as under inflammatory conditions. None of the fatty acids altered the content of mitochondrial DNA, nor did the application of fatty acids induce the generation of proinflammatory cytokines indicating a beneficial profile. It thus can be concluded that short- and medium chained fatty acids can partly restore mitochondrial respiration capacity and therefore are a suitable energy source under inflammatory conditions.

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Hans Matthias Voigtmann

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Entzündungen Sepsis Short chain fatty acids SCFA kurzkettige Fettsäuren langkettige Fettsäuren medium-chain triglycerides MCT

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