Applications of LC-MS in Toxicology
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Beschreibung
Following the developments of LC-MS in the last decade and its establishment as the method of choice in the pharmaceutical industry, the technique is increasingly being used in other scientific disciplines, including Analytical Toxicology.
"Applications of LC-MS in Toxicology" covers all essential theoretical aspects of LC-MS including:
technical details of the instrumentation, method development, optimisation and validation, quantification, maintenance and troubleshooting.
Further chapters cover in detail the application of LC-MS in areas such as:
systematic toxicological analysis, drugs of abuse, therapeutic drug monitoring, doping in sport, pesticides, peptides and further potential forensic applications.
This authoritative text is essential reading for all forensic and clinical toxicologists and will also be useful to pharmaceutical analysis as well as analytical chemists.
Contents:
Ionisation, Ion Separation and Ion Detection in LC-MS
Method Development and Optimisation of LC-MS
Quantification Using LC-MS
Method Validation Using LC-MS: Identification and Confirmation Criteria for LC-MS
Systematic Toxicological Analysis with LC-MS
Analysis of Therapeutic Drugs with LCMS
LCMS of Drugs of Abuse and Related Compounds
LCMS in Doping Control: Pesticide Analysis Using LCMS
Peptide Analysis Using LC-MS
LCMS in Forensic Chemistry
LC-MS in der Toxikologie
Hier erfahren Sie alles, was Sie über LC-MS wissen müssen.
Angesprochen werden technische Geräteangaben, unterschiedliche Bedienungsmodi, Methodik, Optimierung und Validierung, Quantifizierung sowie Kriterien zu Identifizierung und Bestätigung; Sie erhalten detaillierte Informationen zu folgenden LC-MS-Anwendungsbereichen:
* systematische toxikologische Analyse
* Medikamentenmissbrauch
* therapeutisches Drug-Monitoring
* Doping und Sport
* Pestizide
* Peptide und Forensik
Ein Muss für alle Toxikologen in Forensik und Klinik und sinnvoll für pharmazeutische Analyse und analytische Chemie.
Autor*in
Aldo Polettini