Cell and Animal Models in Aging and Dementia Research
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Beschreibung
Although age has been recognized as a risk factor for late-onset dementia of Alzheimer type, its etiology is unknown as yet. Several age-related metabolic abnormalities may thus become important for the pathogenesis of the late-onset form. Studies at the cellular/molecular level in brain tissue are possible post mortem, but lack information on the beginning of the disorder. In this supplement, different approaches are dealt with how to induce structural and/or metabolic abnormalities in relevant cell cultures, in brain slices and in experimental animals, and how behavioral changes parallel the metabolic variations.
This supplement deals with data from cell cultures of different kinds, brain tissue slices and (brain) animal models related to aging and Alzheimer's disease. Results presented concern structural, metabolic and behavioral aspects with the aim to provide approaches which mimic biological variations in the aging and Alzheimer brain to better understand the pathogenesis of the latter disorder.
Autor*in
Siegfried Hoyer
Themen in »Cell and Animal Models in Aging and Dementia Research«
Aging Alzheimer's disease Alzheimer´s disease brain calcium dementia drug ethanol forebrain hypoxia metabolism neurodegenerative disorders neurons neuropathology research