This book provides comprehensive insights into congenital heart disease from embryonic development through to clinical features, including human genetics and our current knowledge of the underlying molecular pathways. It is divided into three parts: an introduction to the development of the heart and its vessels, an overview of the molecular pathways affecting the development of various cardiovascular structures, and a main section focusing on the different types of structural and nonstructural congenital heart diseases, including their clinical features, underlying genetic alterations and related animal models and pathways. Taken together these chapters, which were written by and for clinicians and researchers, provide an integrated and cutting-edge resource for all those who want to learn more about both the clinical aspects and the genetic and molecular basis of congenital heart disease.
This book provides comprehensive insights into congenital heart disease from embryonic development through to clinical features, including human genetics and our current knowledge of the underlying molecular pathways. It is divided into three parts: an introduction to the development of the heart and its vessels, an overview of the molecular pathways affecting the development of various cardiovascular structures, and a main section focusing on the different types of structural and nonstructural congenital heart diseases, including their clinical features, underlying genetic alterations and related animal models and pathways. Taken together these chapters, which were written by and for clinicians and researchers, provide an integrated and cutting-edge resource for all those who want to learn more about both the clinical aspects and the genetic and molecular basis of congenital heart disease.
Silke Rickert-Sperling
cardiac malformation congenital heart disease genomics heart development molecular cardiology transcriptomics
“The book describes the different pathologies comprising congenital heart disease. … The audience is adult or pediatric cardiologists who care for patients with congenital heart disease. … This is a great resource, especially geared for cardiologists or cardiology team members with an existing fundamental knowledge of CHD, as well as those engaged in the bench research side.” (Shawn Ragbir, Doody’s Book Reviews, March, 2016)
“I am very glad that I came across your book "Congenital heart diseases: The Broken Heart" which has become very handy to look into the details of the developmental aspect of different heart diseases with animal models. I bought an electronic book, which I really like. Thank you for bringing out this book. I believe this will help young generation of pediatric cardiologists and researchers to understand the genetic/biological mechanisms of these disorders.” (Laxmi Ghimire, MD, Clinical Fellow, PGY5, Pediatric Cardiology, UCSF Benioff Children's Hospital, San Francisco, CA)