Biosimulation in Biomedical Research, Health Care and Drug Development
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Beschreibung
Biosimulation is an approach to biomedical research and the treatment of patients in which computer modeling goes hand in hand with experimental and clinical work. Constructed models are used to interpret experimental results and to accumulate information from experiment to experiment.
The book explains the concepts used in the modeling of biological phenomena and goes on to present a series of well-documented models of the regulation of various cellular and physiological processes, emphasizing particularly the role of self-sustained biological activity. The way how the use of computer models allows optimization of the treatment of various diseases for individual patients is discussed and models of interacting nerve cells that can be used to design new treatments for patients with Parkinson's disease are explained. Furthermore this volume provides a discussion of the use of models in the pharmaceutical industry, and presents the view of the regulatory agencies on the topic.
Biosimulation is an approach to biomedical research and the treatment of patients in which computer modeling goes hand in hand with experimental and clinical work. Constructed models are used to interpret experimental results and to accumulate information from experiment to experiment.
This book explains the concepts used in the modeling of biological phenomena and goes on to present a series of well-documented models of the regulation of various genetic, cellular and physiological processes. The way how the use of computer models allows optimization of cancer treatment for individual patients is discussed and models of interacting nerve cells that can be used to design new treatments for patients with Parkinson's disease are explained. Furthermore this volume provides an overview on the use of models in industry, and presents the view of regulatory agencies on the topic.
Clear introduction to the modeling of physiological processes and mechanisms Well-documented models of important genetic, cellular and macrophysiological phenomena Model-based treatments of cancer and Parkinson's disease Application of physiologically-based models in the pharmaceutical industry Special chapter presents the views of the regulatory agencies Includes supplementary material: sn.pub/extras
Autor*in
Erik Mosekilde
Themen in »Biosimulation in Biomedical Research, Health Care and Drug Development«
Complex biological processes Mechanism based modeling Model-based drug development Model-based healtcare Systems biology