Development of an Aerated High-Pressure Reactor for Biotechnological Applications
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Beschreibung
This work presents the development and characterizati on of an aerated high-pressure
reactor for biotechnological applicati ons. Enzymati c oxidati on reacti ons are investi -
gated at pressures up to 15 MPa with the aim of overcoming oxygen mass transfer
limitati ons. Opti cal oxygen sensors are employed for reliable online measurements
under high-pressure conditi ons, and gas–liquid mass transfer is experimentally analyzed.
Based on the results, a scalable reactor concept for intensifi ed biotechnological
processes is proposed.
Autor*in
Daniel Niehaus
Themen in »Development of an Aerated High-Pressure Reactor for Biotechnological Applications«
High-Pressure, Aeration, Biotechnology, Oxygen Sensors, Multiphase Flows, Enyzmatic Reactions, Reactor Design Multiphase flows High-pressure bioreactor, Aerated reactor systems, Biocatalytic oxidation Enzymatic reactions under pressure, Process intensification, Gas–liquid mass transfer, Volumetric mass transfer coefficient (kLa) Bubble column reactor, High-pressure bubble dynamics, Bubble size distribution, Gas hold-up Interfacial area, Hydrodynamics under pressure, Oxygen solubility, Oxygen mass transfer limitation Dissolved oxygen measurement, Optical oxygen sensors, Fluorescence quenching, Optical sensor calibration High-pressure sensor technology, Online process monitoring, Enzyme immobilization Glucose oxidase, Enzyme kinetics, Multiphase reactor engineering, High-pressure batch reactor, Laboratory-scale reactor design Reactor characterization, Pressure effects on enzymes, Oxygen availability, Reaction monitoring Mass transport limitations, High-pressure biotechnology, Jet loop reactor, Reactor scale-up Sustainable chemical processing, Green chemistry, Biotechnological process design, Advanced reactor concepts Mehrphasenströmungen Hochdruckbioreaktor, Begaste Reaktorsysteme, Biokatalytische Oxidation Enzymatische Reaktionen unter Druck, Prozessintensivierung, Gas-Flüssig-Stoffübergang Volumenspezifischer Stoffübergangskoeffizient (kLa), Blasensäulenreaktor, Hochdruck-Blasendynamik Blasengrößenverteilung, Gasgehalt, Phasengrenzfläche, Hydrodynamik unter Druck, Sauerstofflöslichkeit