Genome Mapping and Genomics in Human and Non-Human Primates
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Beschreibung
This book provides an introduction to the latest gene mapping techniques and their applications in biomedical research and evolutionary biology. It especially highlights the advances made in large-scale genomic sequencing. Results of studies that illustrate how the new approaches have improved our understanding of the genetic basis of complex phenotypes including multifactorial diseases (e.g., cardiovascular disease, type 2 diabetes, and obesity), anatomic characteristics (e.g., the craniofacial complex), and neurological and behavioral phenotypes (e.g., human brain structure and nonhuman primate behavior) are presented.Topics covered include linkage and association methods, gene expression, copy number variation, next-generation sequencing, comparative genomics, population structure, and a discussion of the Human Genome Project. Further included are discussions of the use of statistical genetic and genetic epidemiologic techniques to decipher the genetic architecture of normal and disease-related complex phenotypes using data from both humans and non-human primates.
This book provides an introduction to the latest gene mapping techniques and their applications in biomedical research and evolutionary biology. It especially highlights the advances made in large-scale genomic sequencing. Results of studies that illustrate how the new approaches have improved our understanding of the genetic basis of complex phenotypes including multifactorial diseases (e.g., cardiovascular disease, type 2 diabetes, and obesity), anatomic characteristics (e.g., the craniofacial complex), and neurological and behavioral phenotypes (e.g., human brain structure and nonhuman primate behavior) are presented.Topics covered include linkage and association methods, gene expression, copy number variation, next-generation sequencing, comparative genomics, population structure, and a discussion of the Human Genome Project. Further included are discussions of the use of statistical genetic and genetic epidemiologic techniques to decipher the genetic architectureof normal and disease-related complex phenotypes using data from both humans and non-human primates.
Will be of interest to scientists in the fields of genetics, evolutionary biology, bioinformatics, genetic epidemiology, pharmacogenetics, anthropology and biomedical research Reviews the key genetic sequencing and mapping techniques An invaluable work that will promote further genomic research Includes supplementary material: sn.pub/extras
Autor*in
Ravindranath Duggirala
Themen in »Genome Mapping and Genomics in Human and Non-Human Primates«
Disease-Related Genes Epidemiology of Aleutian island populations Genetics of cardiovascular diseases Human Genome Project Linkage Mapping Primate craniofacial complex Statistical genetics Transcriptomics gene expression