EGF Receptor in Tumor Growth and Progression
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Beschreibung
Members of the tyrosine kinase family are frequently implicated in experimental as well as in human cancer. The best studied receptor signaling system from this family is the EGF receptor. Experts in this area report on the involvement of the receptor in a variety of human tumors, outline underlying molecular mechanisms for aberrant receptor signaling in experimental systems and present the status of current therapies directed against the receptor. A detailed analysis of EGF receptor signal transduction via expression of receptor, ligands, phosphatases and presence of other members of the receptor family will provide new information for the design of therapeutic modalities targeting this receptor system.
The last 15 years have brought an understanding of growth and differentiation at the molecular level, expanding our knowledge of the origin and progression of cancer. Early breakthroughs defining growth control pathways came via studies of oncogenes, mutated signaling molecules that have lost the capacity to tum off their proliferative signal. Oncogenes with diverse growth-promoting activities have been discovered, covering the gamut from cell surface to nuclear signaling. Sequencing of these oncogenes revealed that they were mutated forms of captured cellular genes and displayed tyrosine kinase activity. The epidermal growth factor (EGF) receptor was the first of 40-50 transmembrane tyrosine kinase receptors to be cloned and sequenced. Beyond cell proliferation, activation of EGF receptor by its specific ligands controls important physiological processes, such as cell differentiation, apoptosis, cell migration, and cell shape. Activation of autocrine growth loops, consisting in solid human tumors of upregulated expression of EGFR together with increased production of ligands suggested its crucial role in autonomous tumor growth.
Autor*in
R.B. Lichtner
Themen in »EGF Receptor in Tumor Growth and Progression«
EGF Receptor EGF Rezeptor Signal Transduction Signaltransduktion Tyrosinkinase angiogenesis antibody breast cancer cancer cancer therapy growth factor tumor tumor growth tumor progression tumorigenesis