Impact of Survivin Acetylation on its Biological Function
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Beschreibung
In his research, David Dannheisig investigates the influence of lysine129 acetylation on the biological function of survivin including alteration of nucleocytoplasmic shuttling as well as dimerization behavior. Since survivin participates in two major hallmarks of oncogenesis, namely cell death inhibition and chromosomal segregation during the cell cycle, it reflects a valuable target in cancer therapy and research. The author establishes proximity-dependent, fluorescence-microscopic methods to quantify the interaction of survivin with the export receptor Crm1 as well as the homodimerization itself. In the future, those systems can be used to examine the feasible effect of chemical modulators which are targeting these interactions in a cellular background. The outcome achieved is an essential step towards the enhancement of potential cancer therapies.
Contents
- Apoptosis – The Programmed Suicide
- Cancer – The Enemy Inside
- Nucleocytoplasmic Transport– Cellular Navigation
- Biological Function of Survivin
- Protein modification – Make-Up for Proteins
- Cell cycle – Virchow’s Heritage
- Lecturers, students and researchers in the biological-medical sector
- Practitioners in the fields of molecular biology, cell biology, fluorescence microscopy, medical biology, protein interaction studies
In his research, David Dannheisig investigates the influence of lysine129 acetylation on the biological function of survivin including alteration of nucleocytoplasmic shuttling as well as dimerization behavior. Since survivin participates in two major hallmarks of oncogenesis, namely cell death inhibition and chromosomal segregation during the cell cycle, it reflects a valuable target in cancer therapy and research. The author establishes proximity-dependent, fluorescence-microscopic methods to quantify the interaction of survivin with the export receptor Crm1 as well as the homodimerization itself. In the future, those systems can be usedto examine the feasible effect of chemical modulators which are targeting these interactions in a cellular background. The outcome achieved is an essential step towards the enhancement of potential cancer therapies.
Study on the Biological Function of Survivin Includes supplementary material: sn.pub/extras
Autor*in
David Dannheisig
Themen in »Impact of Survivin Acetylation on its Biological Function«
FRET Survivin Acetylierung Proteininteraktionsstudien Proximity Ligation Assay (PLA) Zellbiologie Cancer Protein Interaction Studies Survivin Acetylation