RNP Particles, Splicing and Autoimmune Diseases
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Beschreibung
The maturation of the precursors of mRNA to a functional transcript in eukaryotic cells is a complex, multistep process. It includes the formation of RNP complexes and the splicing procedure. Also, the presence of snRNA packaged as snRNP particles plays an important role in this process. In addition, snRNPs are involved in various autoimmune diseases in which autoantibodies are directed against components of these particles.
Relevant techniques to investigate RNA processing, splicing, protein-RNA complex formation and protein-RNA interactions as well as the use of autoantibodies in basic and clinical research are presented in this manual.
Information stored in DNA needs to be translated into functional proteins. Ribonucleoprotein (RNP) particles play a major role in this process. In many autoimmune diseases, antibodies are directed against components of these particles. Detailed protocols for analysing the structure and function of RNPs are described in this manual.
A practical tool for anyone working at the lab bench Easy to follow step-by-step protocols Background information and full practical details
Autor*in
Johannes Schenkel
Themen in »RNP Particles, Splicing and Autoimmune Diseases«
Autoimmunkrankheit RNA RNP particles (ribonucleoprotein particles) Zellkern autoantibodies autoantigens electron microscopy m-RNA splicing