Molecular Diagnostics for Dermatology
Practical Applications of Molecular Testing for the Diagnosis and Management of the Dermatology Patient
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Beschreibung
This textbook presents the current (and near-future) state of affairs of molecular testing as it pertains to the dermatology patient. It focuses on practical applications of molecular diagnostics over a cross-section of dermatologic disease, including melanoma, lymphoma, soft tissue tumors, genodermatoses, and infectious disease. It includes practical advice to those ordering molecular tests as well as to those considering performing such tests, providing a potential template for a comprehensive dermatologic molecular diagnostics test menu. Pitfalls of interpretation and algorithmic approaches to testing are included. The textbook is directed towards all readers – clinicians, pathologists, laboratorians, and other inquisitive minds – independent of their level of molecular expertise, to provoke thought or perhaps even change practice.
The context for the book is the rapid evolution of the field of molecular diagnostics, which is becoming more pervasive in all disciplines of medicine, including dermatology. This is indeed an exciting time in dermatology. Molecular testing is now incorporated into all aspects of patient management, including diagnostics (identifying and classifying disease), prognostics (predicting disease course), and theranostics (predicting response to therapy). For example, molecular tests are now used to detect germline mutations that result in genodermatoses, somatic genetic events that characterize tumors such as melanoma and sarcomas, and genetic material of otherwise undetectable infectious organisms. For melanoma and lymphoma, testing can potentially predict tumor behavior and modify patient staging. Regarding theranostics, molecular tests that identify specific mutations in proto-oncogenes, such as BRAF and others, are now used to predict which patients will respond to designer targeted therapies. Molecular theranostics has revolutionized the entiretreatment paradigm for patients with advanced melanoma, replacing “excise and pray” approaches with personalized medicine.
Molecular diagnostics is an exploding field, and recent advances in our understanding of the molecular basis of disease have provided a platform for the development of new diagnostic tests as well as tests to predict tumor behavior and potential response to targeted therapy. This textbook provides a reference and practical guide to molecular diagnostics for dermatologists and dermatopathologists. It outlines our current understanding of the molecular underpinnings of dermatologic disease, describes the appropriate use of currently available molecular tests, and explains the interpretation of these tests in the context of diagnosis and management. Tests relating to various disorders are covered, including but not confined to melanoma, genodermatoses, and infectious disease. Pitfalls are highlighted and user-friendly algorithmic approaches, presented.
Emphasis on practical applications of molecular testing in diagnosis and management Offers insights into the interpretation of tests Explains pitfalls and presents user-friendly algorithmic approaches Includes bullet points highlighting key information for easy application
Autor*in
Gregory A. Hosler
Themen in »Molecular Diagnostics for Dermatology«
Dermatopathology Genodermatoses Melanoma Pharmacogenetics Theranostics
Stimmen zu »Molecular Diagnostics for Dermatology«
From the book reviews:
“This is an outstanding reference that thoroughly explains dysfunctional molecular pathways causing the development of skin cancer. … The audience is dermatologists and any medical care professionals involved in treating patients with skin cancers. … This book is a gem. Every page should be studied.” (Patricia Wong, Doody’s Book Reviews, January, 2015)()