Coarse-Grained Modelling of DNA and DNA Self-Assembly
Buch in deiner Nähe kaufen
Beschreibung
This thesis presents a novel coarse-grained model of DNA, in which bases are represented as rigid nucleotides. The model is shown to quantitatively reproduce many phenomena, including elastic properties of the double-stranded state, hairpin formation in single strands and hybridization of pairs of strands to form duplexes, the first time such a wide range of properties has been captured by a coarse-grained model. The scope and potential of the model is demonstrated by simulating DNA tweezers, an iconic nanodevice, and a two-footed DNA walker — the first time that coarse-grained modelling has been applied to dynamic DNA nanotechnology.
This thesis presents a novel coarse-grained model of DNA, in which bases are represented as rigid nucleotides. The model is shown to quantitatively reproduce many phenomena, including elastic properties of the double-stranded state, hairpin formation in single strands and hybridization of pairs of strands to form duplexes, the first time such a wide range of properties has been captured by a coarse-grained model. The scope and potential of the model is demonstrated by simulating DNA tweezers, an iconic nanodevice, and a two-footed DNA walker — the first time that coarse-grained modelling has been applied to dynamic DNA nanotechnology.
Nominated as an outstanding contribution by the University of Oxford Presents a novel model with remarkable explanatory power Holds important potential for dynamic DNA nanotechnology Includes supplementary material: sn.pub/extras Includes supplementary material: sn.pub/extras
Autor*in
Thomas E. Ouldridge
Themen in »Coarse-Grained Modelling of DNA and DNA Self-Assembly«
Biological Motors Coarse Grained Molecular Simulation DNA Nanotechnology DNA Tweezers DNA Walker Molecular Self-Assembly Monte Carlo Algorithms