Nevogenesis
Mechanisms and Clinical Implications of Nevus Development
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Beschreibung
Paul Gerson Unna’s “Abtropfung” theory that nevi develop through migration of nevus cells from the epidermis to the dermis prevailed for almost a century until the “Hochsteigerung” theory postulated the reverse pattern of migration based on newly acquired observations from histopathology and studies of embryogenesis. Most recently, however, new insights gained from epidemiology, cross-sectional and longitudinal studies of nevi, dermoscopy and confocal microscopy, and cellular and molecular studies have brought into question both of the aforementioned theories. This book provides a comprehensive guide to current knowledge about nevogenesis by presenting these latest advances and in addition discusses issues yet to be resolved. It will assist practicing physicians in effectively managing patients with a variety of nevi and will also be of great value to researchers in the field. Importantly, since nevi are associated with an increased risk of melanoma, understanding nevogenesis may help to unravel some of the mysteries of melanomagenesis.
The “Abtropfung” theory that nevi develop through the migration of nevus cells from the epidermis to the dermis prevailed for almost a century until the “Hochsteigerung” theory postulated the reverse pattern of migration. Most recently, however, new insights gained from epidemiology, cross-sectional and longitudinal studies of nevi, dermoscopy and confocal microscopy, and cellular and molecular studies have brought into question both of these theories. This book provides a comprehensive guide to current knowledge about nevogenesis by presenting these latest advances and in addition discusses issues yet to be resolved. It will assist practicing physicians in effectively managing patients with a variety of nevi and will also be of great value to researchers in the field. Importantly, since nevi are associated with an increased risk of melanoma, understanding nevogenesis may help to unravel some of the mysteries of melanomagenesis.
A detailed update on current knowledge of nevogenesis Presents the latest evidence from a wide variety of studies Will help practicing physicians to manage patients with a variety of nevi and assist researchers in the field of nevogenesis and melanomagenesis Includes supplementary material: sn.pub/extras
Autor*in
Ashfaq A. Marghoob
Themen in »Nevogenesis«
Growth and evolution of nevi Involution Melanoma Nevus development Senescence
Stimmen zu »Nevogenesis«
From the reviews:
“The purpose is to provide an update on how nevi are formed, their evolution, and factors that influence their development. I haven’t read any other book that addresses this subject in this depth. The authors do a superb job. … This should be required reading for all dermatology residents and dermatologists out of training.” (Patricia Wong, Doody’s Book Reviews, June, 2013)()