Assessing the Functional Structure of Molecular Transporters by EPR Spectroscopy

Beschreibung

In his thesis, Matthias Junk takes an innovative approach to assess the local structure and dynamics of biological and synthetic amphiphilic macromolecules capable of transporting small molecules. Replacing the latter with stable radicals, he uses state-of-the-art electron paramagnetic resonance (EPR) spectroscopy to describe the highly relevant transport function from the viewpoint of the guest molecules. Such, he demonstrates that the functional structure of human serum albumin in solution significantly differs from its crystal structure – a consequence of the protein’s adaptability to host various endogenous compounds and drug molecules. Further, he shows that the thermal collapse of thermoresponsive hydrogels and dendronized polymers leads to static and dynamic heterogeneities on the nanoscale. These heterogeneities bear consequences for the material’s hosting properties and enable unforeseen complex catalytic functionalities.
In his thesis, Matthias Junk takes an innovative approach to assess the local structure and dynamics of biological and synthetic amphiphilic macromolecules capable of transporting small molecules. Replacing the latter with stable radicals, he uses state-of-the-art electron paramagnetic resonance (EPR) spectroscopy to describe the highly relevant transport function from the viewpoint of the guest molecules. Such, he demonstrates that the functional structure of human serum albumin in solution significantly differs from its crystal structure – a consequence of the protein’s adaptability to host various endogenous compounds and drug molecules. Further, he shows that the thermal collapse of thermoresponsive hydrogels and dendronized polymers leads to static and dynamic heterogeneities on the nanoscale. These heterogeneities bear consequences for the material’s hosting properties and enable unforeseen complex catalytic functionalities.
Nominated by Max-Planck-Institute for Polymer Research, Mainz, Germany Innovative approach to assess the topic Delivers remarkable new insights into materials Includes supplementary material: sn.pub/extras

Autor*in

Matthias J.N.Junk

Themen in »Assessing the Functional Structure of Molecular Transporters by EPR Spectroscopy«

DNP EPR/ESR spectroscopy LCST dynamic nuclear polarization binding sites of albumin, fatty acids, transport protein biomimetic systems cholic acids dynamics of macromolecular systems metal ion sensor thermoresponsive polymer umbrella shaped molecules

Stimmen zu »Assessing the Functional Structure of Molecular Transporters by EPR Spectroscopy«

Details

Link teilen