Heteroaromatic Lipoxin A4 Analogues
Synthesis and Biological Evaluation
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Beschreibung
In this thesis Colm Duffy reviews the chemistry and biology of stable lipoxin analogues. Colm has prepared for the first time ever a pyridine-containing LXA4 analogue in enantiomerically pure form. Biological evaluation determined that both epimers at the benzylic position suppress key cytokines known to be involved in inflammatory disease, with the (R)-epimer proving most efficacious. Moreover the author developed an excellent route to a related thiophene-containing analogue that also showed interesting biological activity. Both routes have inspired further work in the synthesis of further heteroaromatic analogues for biological evaluation.
In this thesis Colm Duffy reviews the chemistry and biology of stable lipoxin analogues. Colm has prepared for the first time ever a pyridine-containing LXA4 analogue in enantiomerically pure form. Biological evaluation determined that both epimers at the benzylic position suppress key cytokines known to be involved in inflammatory disease, with the (R)-epimer proving most efficacious. Moreover the author developed an excellent route to a related thiophene-containing analogue that also showed interesting biological activity. Both routes have inspired further work in the synthesis of further heteroaromatic analogues for biological evaluation.
Nominated by University College Dublin as an outstanding PhD thesis Author describes for the first time the synthesis of an enantiomerically pure form of pyridine-containing LXA4 Description of an excellent route to a thiophene-containing LXA4 analogue Includes supplementary material: sn.pub/extras
Autor*in
Colm Duffy
Themen in »Heteroaromatic Lipoxin A4 Analogues«
Aromatic Lipoxin A4 analogues Lipoxin analogues phagocytosis of apoptotic PMN's Stable Lipoxins Zirconium tetrachloride protection/deprotection methodology pro-inflammatory cytokine