Drug Discovery and Evaluation: Methods in Clinical Pharmacology
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Beschreibung
These three volumes offer an overview on all aspects of clinical pharmacology. They divide the discovery and evaluations of new drugs into three distinct steps that expedite and facilitate this increasingly time-consuming and costly process.
Drug Discovery and Evaluation has become a more and more difficult, expensive and time-consuming process. The effect of a new compound has to be detected by in vitro and in vivo methods of pharmacology. The activity spectrum and the potency compared to existing drugs have to be determined.
As these processes can be divided up stepwise we have designed a book series "Drug Discovery and Evaluation" in the form of a recommendation document. The methods to detect drug targets are described in the first volume of this series "Pharmacological Assays" comprising classical methods as well as new technologies. Before going to man, the most suitable compound has to be selected by pharmacokinetic studies and experiments in toxicology. These preclinical methods are described in the second volume „Safety and Pharmacokinetic Assays". Only then are first studies in human beings allowed. Special rules are established for Phase I studies. Clinical pharmacokinetics are performed in parallel with human studies on tolerability and therapeutic effects. Special studies according to various populations and different therapeutic indications are necessary. These items are covered in the third volume: „Methods in Clinical Pharmacology".
As with the earlier books, this volume will be of interest to a broad range of people involved in drug research, chemists, pharmacists, pharmacologists, research institutes in academia and industry, registration authorities, but in peculiar to every physician testing and using drugs. The intention is to have a kind of 'recipe-book' in the respective areas, therefore the different chapters have a quite similar predefined structure. The characteristics in clinical pharmacology are of interest not only to the specialist but also to all physicians working in general practice.
A landmark in the continuously changing world of drugs
Easy-to-use, method-orientated overview on all aspects of Clinical Pharmacology
Essential reading for pharmacologists, physicians, medicinal chemists and pharmacists at research institutes and in industry
Of use for governmental institutions and committees working on official guidelines for drug evaluation worldwide
The three volumes that comprise Drug Discovery and Evaluation are recommendation texts that divide the discovery and evaluation of new drugs into three distinct steps that expedite and facilitate the increasingly difficult, time-consuming, and costly pharmacological process. The first volume describes classical methods and new technologies used to detect drug targets. The second volume details the preclinical methods guiding the pharmacokinetic studies and experiments used to choose the most suitable compound. And the third volume covers all relevant information regarding the first studies in humans. Thorough, up-to-date and easy-to-use, this overview on all aspects of Clinical Pharmacology is essential for pharmacologists, physicians, medical chemists and pharmacists in either university or industry research as well as government institutions and committees working on official guidelines from drug evaluations worldwide.
Autor*in
H.Gerhard Vogel