Studies of Aging
Protocols
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Beschreibung
Interest in the study of the biology of aging (Gerontology), especially as it relates to humans (Geriatrics), has increased steadily in the last 50 years and continues today to be at the forefront of experimental biology. Due to the many recent advances in this area, a large variety of techniques are available and selection of the best experimental approach may be difficult. It is the purpose of this laboratory manual to provide the researcher with a specific group of techniques with emphasis on practical, hands-on information.
A variety of protocols using molecular, cellular and physiological techniques are presented in detail and appropriate animal models have been selected for the study of aging and aging-related diseases. Non-invasive in vivo techniques are described for the study of Alzheimer's dementia and cardiovascular diseases. Techniques for detection of oxidative processes are presented to explore the role of free radicals in causing cell damage and mutations as well as techniques to study apoptosis (programmed cell death) for its role in cell death and aging processes.
Interest in the study of the biology of aging especially as it relates to humans has increased steadily in the last 50 years and continues today to be at the forefront of experimental biology. Due to the many recent advances in this area selection of the best experimental approach may be difficult. It is the purpose of this laboratory manual to provide the researcher with a specific group of techniques with emphasis on hands-on information. A variety of protocols using molecular, cellular and physiological techniques are presented in detail and appropriate animal models have been selected for the study of aging and aging-related diseases. Non-invasive in vivo techniques are described for the study of Alzheimer's dementia and cardiovascular diseases. Techniques for detection of oxidative processes are presented to explore the role of free radicals in causing cell damage and mutations as well as techniques to study apoptosis for its role in cell aging.
Easy-to-follow step-by-step instructions for immediate use at the lab bench Protocols with a uniform clear structure and layout, which allow the techniques to be sucessfully reproduced All necessary practical details and notes as well as a troubleshooting section are included Up-to-date methods written by experts in their fields
Autor*in
Hal Sternberg
Themen in »Studies of Aging«
Alzheimer's disease Alzheimer´s disease DNA Vivo aging cell cell death dementia geriatrics gerontology migration oxidative stress senescence skin tissue