Toxicology- From Cells to Man

Beschreibung

This volume contains the main papers presented at the 1995 EUROTOX Congress, Prague, Czech Republic, August 27 - 30, 1995. Cellular and subcellular models are used to improve our knowledge about mechanistic aspects of toxicological effects, and ultimately this deepened knowledge may serve to further improve our ability to cope with toxicological processes in man. This is reflected in symposia and workshops on intercellular communication, functional teratogenicity, risk assessment of heterocyclic amines in food, clinical toxicology of peptides and proteins, human immunotoxicity and individual susceptibility to occupational toxicants. Progresses in the fields of renal toxicology, metal antidotes and free radicals as well as increased awareness of ecotoxicological problems and effects in Central Europe are also discussed. A highlight of the Congress was certainly the first Gerhard Zbinden Memorial Lecture on alterations of cell signalling in chemical toxicity.
Renal transport and xenobiotic metabolism play an important role in the detoxication and excretion of potentially toxic xenobiotics. However, recent experimental evidence has demonstrated that renal xenobiotic metabolism and renal transport processes also play an important role in the nephrotoxicity of xenobiotics and xenobiotic metabolites. The high blood flow to the kidney combined with its ability to concentrate solutes may expose the kidney to high concentrations of xenobiotics and xenobiotics metabolites present in the systemic circulation. Recently, it has been demonstrated that xenobiotic metabolites formed in the liver and other organs may be targeted to the kidney by selective transport systems~ many xenobiotics require enzymatic transformation to proximate reactive metabolites to elicit their toxic and carcinogenic effects. The enzymatic formation of reactive metabolites is termed bioactivation. The bioactivation mechanisms for many nephrotoxicants have, at least in part, been elucidated in the past 15 years. Many ultimate toxicants formed in the kidney are electrophiles whose interaction with cellular macromolecules may cause a perturbation of normal cell function resulting in necrosis and/or cancer (Anders 1988). Electrophilic metabolites may bind to nucleophilic sites in cellular macromolecules~ the importance of covalent modification of protein and DNA in cell killing and in the induction of tumors is established (Miller and Miller 1981~ Nelson and Pearson 1990~ Hinson and Roberts 1992). The objective of this review is to summarize new information about renal transport, renal bioactivation and their relation to nephrotoxicity using two relevant example for the basic mechanisms outlined above.

Autor*in

Jürg P. Seiler

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DNA asthma cytokine developmental neurotoxicology ecotoxicology environment infectious disease metabolism neurotoxicology pesticide protein proteins resistance toxicity toxicology

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