Respiratory System
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Beschreibung
This is the second edition of a monograph which provided a concise approach to an understanding of the spontaneous and induced lesions in the respiratory system of laboratory animals, especially the rat, mouse, and hamster. This expanded edition keeps the basic format of the first edition but provides much more information applicable to the study of toxicologic pathology. For example, the effects of inhaled toxicants of the upper respiratory tract are presented in detail in relation to the specific cells affected, based upon their precise morphology and function discerned at the ultrastructural level. This approach is followed through the entire volume, with precise identification of the cells preceding consideration of perturbations caused by toxicants of other etiologic agents. Current understanding of the nature and significance of pathologic lesions is probed throughout the volume. Although toxicologic pathology is emphasized, experimental pathologists and other scientists will find this book especially useful.
Approximately ten years have elapsed since the second volume of the International Life Sciences Institute (ILSI) Monographs on Pathology of Laboratory Animals, Respiratory System, was first completed. New in formation of interest to pathologists has developed at a rather remark able pace during these years. Exceptional progress has been made in the routine identification of enzymes and cell products in respiratory cells. A better understanding has developed on the functions of cells of the respiratory tract and of the mechanisms involved in cell metabolism, particularly those involving toxins and carcinogens. Clear concepts have developed concerning the significance of pathologic lesions, particularly in the upper respiratory tract and their relation to human health and risk assessment. Standardized nomenclature has developed significantly dur ing the lO-year period since the first edition and is being utilized on an international basis. This has resulted in significant improvement in com munication of pathologic data to regulatory agencies and in scientific publications worldwide. This monograph series and others sponsored by ILSI have had significant effects on these improved communications and the international acceptance of standardized nomenclature. In this sec ond edition, new formats have been used where more appropriate for the subjects to be covered.
Autor*in
Thomas C. Jones
Themen in »Respiratory System«
Atmungsorgane Lipoprotein Lunge System anatomy carcinoma cell embryo histology lipide lung neoplasms pathology respiration respiratory system